Threshold : 5 - 10mg
Light : 10 - 20mg
Common : 20 - 30mg
Strong : 30 - 40mg
Heavy : 40mg +
Total Duration : 6 - 8 hours
Onset : 20 - 60 minutes
Initial effects : 15 - 30 minutes
Peak : 3 - 6 hours
Coming down : 3 - 5 hours
After effects : 2 - 5 hours
4-HO-MiPT (miprocin, 4-hydroxy-N-methyl-N-isopropyltryptamine, or hats) is an synthetic compound and a lesser-known psychedelic tryptamine. It is thought to be a serotonergic psychedelic, similar to 4-AcO-DMT, LSD and DMT. Its molecular structure and pharmacological effects resemble those of the tryptamine psilocin, which is the primary psychoactive chemical in magic mushrooms.
This substance is relatively uncommon and has only a short history of human use. It was presumably first synthesized by Alexander Shulgin. Its synthesis is described in his book TiHKAL along with reports by people who had ingested the compound. Shulgin’s trials and other anecdotal information suggest that 4-HO-MiPT is similar in activity to psilocin.
In terms of its chemistry, 4-HO-MiPT is the 4-hydroxyl analog of the substituted tryptamine known as MiPT (N-methyl-N-isopropyltryptamine) as well as the isopropyl homolog and structural analog of 4-HO-DMT (Psilocin).
In terms of its pharmacology, 4-HO-MiPT’s psychedelic effects are believed to come from its efficacy at the 5-HT 2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.
- Spontaneous tactile sensations - The “body high” of 4-HO-MiPT can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
- Sedation - In terms of its effects on the physical energy levels of the tripper, 4-HO-MiPT is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.
- Runny nose
- Watery eyes
The cognitive effects of 4-HO-MiPT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a large number of typical and unique psychedelic cognitive effects.
The most prominent of these typical effects generally include:
- Enhancement of current mind state
- Connectivity of thought
- Feelings of fascination, importance and awe
- Time distortion
- Removal of cultural filter
- Feelings of predeterminism
- Conceptual thinking
- Direct communication with the subconsious
- Ego suppression, loss and death
- Feelings of interdependent opposites
- States of unity and interconnectedness
- Enhancement and suppression cycles - This can be described as constant waves of extremely stimulated and profound thinking which are spontaneously surpassed in a cyclic fashion by waves of general thought suppression and mental intoxication. These two states seem to switch between each other in a consistent loop once every 20 - 60 minutes.
4-HO-MiPT presents a full and complete array of possible visual enhancements which generally includes:
As for visual distortions and alterations, effects experienced are detailed below:
- Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, realistic, slow and smooth in motion and static in appearance.
- After images
- Texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, unimmersive in depth and consistent in intensity. The visuals have a very “natural” feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.
4-HO-MiPT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:
- Internal hallucinations (Autonomous entities, Settings, sceneries, and landscapes, Alterations in perspective and Scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a religious, spiritual, mystical, science fiction or transcendental nature in their overall theme.
The auditory effects of 4-HO-MiPT are common in their occurrence and exhibit a full range of effects which commonly include:
Physical Health Effects, Potential Addiction and Tolerance:
The toxicity and long term health effects of recreational 4-HO-MiPT use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-HO-MiPT is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4-HO-MiPT within the psychonaut community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).
There is no current data for the LD50 of 4-HO-MiPT, but it is thought to be high.
4-HO-MiPT does not seem to be physically addictive and many users experience a self-regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.
- Sweden: Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-MiPT as a “health hazard” under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of November 1, 2005, making it illegal to sell or possess.
- United Kingdom: The substance could be considered illegal in the UK under the Misuse of Drugs Act of 1971.
- United States: 4-HO-MiPT is an unscheduled drug in the United States. However, it is an analog of psilocin, which could lead to prosecution under the Federal Analog Act.
4-HO-MiPT induces a generic yet worthwhile tryptamine experience which can be described as almost indistinguishable from that of psilocybin mushrooms and 4-AcO-DMT. It also has the same dosage range to that of 4-AcO-DMT and I would recommend this substance to anybody who is interested in experiencing psychedelia.
General Description of INTPs
- - Tend to see distinctions and inconsistences in thought and language.
- - Detect contradictions in statements.
- - Only statements that are logical and coherent carry weight.
- - External authority per se is irrelevant.
- - Prize intelligence.
- - Intellectual dilettantes.
- - Obsessed with analysis.
- - May show impatience at times with others less endowed intellectually.
- - Arrogant.
- - Should not be asked to work out the implementation or application of their models.
- - They may have difficulty expressing their emotions verbally.
- - Are very adaptable until one of their principles is violated.
- - INTP architect.
- - Reluctance to state the obvious.
- - Questions everything and bases answers on laws and principles.
- - An excellent decision maker and can be counted on to remember and to honor decisions.
- - “Portrait painter of ideas.”
- - Imaginative.
- - Responsive to whatever new data present themselves.
- - Make a coherent whole out of an endlessly proliferating amount of data.
- - All thoughts, ideas and plans, however final they seem, are subject to last-minute changes when “new data’, from either internal or external influences, become available.
- - They are the first to knock down their own theories or correct themselves with a better word or improved idea.
- - Create a plan open-ended enough to allow for improvements.
- - Wants to critique and improve the “rough draft.”
- - Once an INTP thinks a project through, he or she may lose interest in it.
- - When an INTP female’s feeling side does surface, it often does so with an intensity, an outpouring that can be frightening to both herself and others.
- This type may be eager to negotiate. They will study the concept of negotiations and be interested in looking at mediation and negotiating options as contrasted with litigation. They may want to know more about negotiation.
- This type will look for common values that can be shared and will apply them to disputes.
- Will be good at working out facts and figures.
- Once agreement is reached, this type will not want to return to the subject. It’s now complete (closed).
- Careful of details.
- This type will look for “win-win” options - a good problem solver.
- This type can handle complications until it seems too repetitious.
- Likes problem-solving.
- They can handle intense negotiations.
Weaknesses as negotiators
- Under stress the INTP may have pain and distress that is new and not understood. No outlet for terrible internal pain and loss. May find it difficult to meet his spouse.
- The INTP doesn’t take care of himself enough - not tuned in to own personal needs. What INTP sees as fair may skip their own personal needs.
- The INTP may become highly positional where intensely personal issues are involved or where his space is invaded.
- They need to think before deciding.
- It is hard for INTPs to communicate their feelings while negotiating.
- They get lost if details are repetitious.
- May have trouble concentrating on specifics.
- They may have trouble coming to a final decision.
- INTPs may put too many items on the agenda.
- They may become hairsplitting in details.
- If it gets too personal the INTP may withdraw.
- If it gets too emotional the INTP may forget what was said.
How INTPs see themselves as negotiators
- They are creative, logical, reasonable.
- They are accurate, tough-minded and fair.
- They seek justice.
How others see INTPs as negotiators
- They are seen as cold, repressed and arrogant.
- They are seen as uncaring about people.
How to work positively with other types
- Appreciate your ability to adapt.
- Appreciate your ability to be creative and insightful.
MDMA and LSD as therapeutic drugs
Kupferschmidt offers two pieces in Science magazine on using two currently banned classes of drugs for therapeutic purposes: the party drug ecstacy (3,4-methylenedioxymethamphetamine, or MDMA), and hallucinogenic compounds derived from fungus or mushrooms (LSD and psilocybin).
MDMA activates brain receptors for dopamine and noradrenaline and releases serotonin from nerve endings, leading to the characteristic feeling of euphoria that made it popular in clubs and at dance events. One study in which 10 out of 12 PTSD patients no longer met the diagnostic criteria for PTSD after two months of taking MDMA has motivated the launching of phase II clinical studies in Israel, Canada, and the United States.
LSD and psilocybin, which bind to serotonin and other brain receptors, are being tested in studies to treat depression, obsessive-compulsive disorder, anxiety, cluster headaches, and nicotine, alcohol, or cocaine addictions.
From Deric Bownds’ MindBlog
Gimme LSD and psilocybin, like now.
Like right now.